Nucleotide transport

Across TCGA patient cohorts, RNA activity of the Nucleotide transport pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are BTK, DEF6, and ANKRD44, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nucleotide transport activity versus BTK in GBM (Pearson r = 0.31).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	BTK →	+0.447	+0.033	<.001	<.001	3	7
BRCA	DEF6 →	+0.301	+0.029	.001	<.001	3	7
LSCC	ANKRD44 →	+0.324	+0.034	<.001	<.001	3	7
BRCA	LCP1 →	+0.460	+0.028	<.001	<.001	3	7
BRCA	ARHGAP25 →	+0.443	+0.023	<.001	<.001	3	7
CCRCC	RENBP →	+0.333	+0.033	.003	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006862 vs BTK — GBM

Explore this scatter interactively →