Nucleotide transport

Across TCGA patient cohorts, RNA activity of the Nucleotide transport pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TASOR, ETNK2, and H2BC12, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nucleotide transport activity versus TASOR in PDAC (Pearson r = -0.21).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	TASOR →	-0.245	-0.193	.003	.006	3	4
CCRCC	ETNK2 →	+0.925	+0.171	.008	.007	3	3
CCRCC	H2BC12 →	-0.376	-0.199	.008	.004	3	3
CCRCC	SERPINB9P1 →	-0.812	-0.179	<.001	.002	3	3
CCRCC	HNRNPKP5 →	-0.314	-0.183	.001	.002	3	3
GBM	ZDHHC9 →	+0.590	+0.213	.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006862 vs TASOR — PDAC

Explore this scatter interactively →