Nucleotide transport

Across TCGA cell cohorts, RNA activity of the Nucleotide transport pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LASP1, ATP8B3, and DRAM1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, LASP1 grouped by Nucleotide transport-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	LASP1 →	-2.141	-1.381	<.001	<.001	3	6
LUNG_SCLC	ATP8B3 →	-1.926	-1.125	.008	.001	3	5
LUNG_SCLC	DRAM1 →	-2.320	-1.049	.006	.007	2	6
OESOPHAGUS	TRAM1 →	-1.098	-1.315	<.001	<.001	3	5
OESOPHAGUS	WFS1 →	-0.976	-1.392	.002	<.001	3	5
OESOPHAGUS	CIR1 →	-0.825	-1.070	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LASP1 by Nucleotide transport activity — LUNG_SCLC

Explore this box plot interactively →