Extracellular transport

Across TCGA patient cohorts, RNA activity of the Extracellular transport pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are WDR54, DPCD, and IFT74, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Extracellular transport activity versus WDR54 in BRCA (Pearson r = 0.56).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	WDR54 →	+0.522	+0.067	<.001	<.001	3	8
LSCC	DPCD →	+0.699	+0.109	<.001	<.001	3	8
GBM	IFT74 →	+0.443	+0.088	<.001	<.001	3	8
BRCA	IFT88 →	+0.527	+0.089	<.001	<.001	3	8
BRCA	LZTFL1 →	+0.710	+0.088	<.001	<.001	3	8
BRCA	TRAF3IP1 →	+0.484	+0.071	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006858 vs WDR54 — BRCA

Explore this scatter interactively →