Extracellular transport

Across TCGA cell cohorts, RNA activity of the Extracellular transport pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TPM1, MRPS34, and CHIC2, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Extracellular transport activity versus TPM1 in BONE (Pearson r = 0.93).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	TPM1 →	+6.254	+2.141	.001	.001	3	10
LUNG_NSCLC_LUSC	MRPS34 →	-0.907	-1.844	<.001	<.001	3	6
SKIN	CHIC2 →	+0.776	+0.865	.001	.002	3	5
LIVER	ITGB1 →	+1.933	+1.008	<.001	.007	3	5
LUNG_NSCLC_LUAD	PXDC1 →	+1.700	+1.039	<.001	.001	3	5
LUNG_NSCLC_LUAD	PAM16 →	-0.757	-1.138	.004	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006858 vs TPM1 — BONE

Explore this scatter interactively →