Xenobiotic transmembrane transport

Across TCGA patient cohorts, RNA activity of the Xenobiotic transmembrane transport pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SLC25A13, PRNP, and BCL2L12_S242, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Xenobiotic transmembrane transport activity versus SLC25A13 in COAD (Pearson r = 0.33).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	SLC25A13 →	+0.561	+0.046	<.001	<.001	3	7
PDAC	PRNP →	-0.221	-0.035	.003	.004	3	6
HNSC	BCL2L12_S242 →	-0.528	-0.066	.005	.008	3	5
HNSC	AKAP1 →	+0.326	+0.076	<.001	<.001	3	5
CCRCC	APOL2 →	-0.816	-0.077	<.001	<.001	3	5
COAD	DIAPH2 →	+0.249	+0.037	.006	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006855 vs SLC25A13 — COAD

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