Xenobiotic transmembrane transport

Across TCGA patient cohorts, RNA activity of the Xenobiotic transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SMIM14, DHX15, and MIR588, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Xenobiotic transmembrane transport activity versus SMIM14 in BRCA (Pearson r = 0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SMIM14 →	+1.561	+0.333	<.001	<.001	3	4
GBM	DHX15 →	-0.219	-0.508	.007	.004	3	4
OV	MIR588 →	+0.834	+0.523	.004	.005	3	3
LSCC	ZBTB16 →	+0.764	+0.577	.009	.008	3	3
LUAD	ATP13A4 →	+1.067	+0.315	.001	.003	3	3
LUAD	CYP4Z2P →	+1.207	+0.398	.004	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006855 vs SMIM14 — BRCA

Explore this scatter interactively →