Xenobiotic transmembrane transport

Across TCGA patient cohorts, RNA activity of the Xenobiotic transmembrane transport pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ABCC3, ABCC3_S908, and ABCC4_S404, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Xenobiotic transmembrane transport activity versus ABCC3 in LUAD (Pearson r = 0.38).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	ABCC3 →	+0.883	+0.608	<.001	<.001	3	5
GBM	ABCC3_S908 →	+0.781	+0.717	<.001	<.001	3	5
UCEC	ABCC4_S404 →	+1.052	+0.567	<.001	<.001	3	5
UCEC	TM9SF4 →	+0.455	+0.545	<.001	<.001	3	4
UCEC	RBBP4 →	-0.300	-0.728	<.001	.001	3	4
UCEC	SYNGR2 →	+0.530	+0.743	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006855 vs ABCC3 — LUAD

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