Xenobiotic transmembrane transport

Across TCGA cell cohorts, RNA activity of the Xenobiotic transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C11orf49, NOP58, and SMYD4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Xenobiotic transmembrane transport activity versus C11orf49 in LUNG_SCLC (Pearson r = 0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	C11orf49 →	+1.058	+1.128	.001	.002	3	4
PANCREAS	NOP58 →	-0.516	-0.493	.004	.004	3	4
SOFT_TISSUE	SMYD4 →	-0.835	-0.487	.002	<.001	3	4
BLOOD_Myeloma	HERC4 →	-1.113	-0.267	.004	.009	3	3
BLOOD_Myeloma	TGIF1 →	-3.627	-0.295	<.001	.001	3	3
LIVER	PLAC8 →	+3.558	+0.360	.005	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006855 vs C11orf49 — LUNG_SCLC

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