Pyruvate transport

Across TCGA patient cohorts, RNA activity of the Pyruvate transport pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SLC16A3, SRP9, and ATG3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pyruvate transport activity versus SLC16A3 in GBM (Pearson r = 0.61).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SLC16A3 →	+0.748	+0.117	<.001	<.001	3	6
GBM	SRP9 →	-0.306	-0.092	<.001	<.001	3	6
LUAD	ATG3 →	+0.190	+0.062	<.001	.005	3	5
COAD	EIF4G1 →	+0.181	+0.050	<.001	<.001	3	5
GBM	GYS1 →	+0.326	+0.076	<.001	<.001	3	5
BRCA	ARHGEF12 →	-0.320	-0.100	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006848 vs SLC16A3 — GBM

Explore this scatter interactively →