Pyruvate transport

Across TCGA patient cohorts, RNA activity of the Pyruvate transport pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZSCAN32, ALOX12P1, and TPI1P4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pyruvate transport activity versus ZSCAN32 in CCRCC (Pearson r = -0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	ZSCAN32 →	-0.194	-0.199	<.001	<.001	3	4
CCRCC	ALOX12P1 →	-0.180	-0.148	.005	.006	3	4
BRCA	TPI1P4 →	+0.811	+0.627	.002	.006	3	3
BRCA	RPL7P1 →	+0.665	+0.474	.005	.007	3	3
BRCA	EEF1A1P17 →	+0.436	+0.627	<.001	.009	3	3
CCRCC	PPIAP67 →	-0.389	-0.224	.006	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006848 vs ZSCAN32 — CCRCC

Explore this scatter interactively →