Pyruvate transport

Across TCGA cell cohorts, RNA activity of the Pyruvate transport pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HOOK3, RHEB, and SPIN1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pyruvate transport activity versus HOOK3 in CNS (Pearson r = -0.75).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	HOOK3 →	-0.899	-2.070	.002	<.001	3	3
BLOOD_Myeloma	RHEB →	+1.000	+0.349	.004	.008	3	3
STOMACH	SPIN1 →	+1.420	+0.295	.002	.003	2	4
BLOOD_Myeloma	ADRB2 →	+3.870	+0.392	.002	.009	2	4
BLOOD_Myeloma	JAK2 →	+1.030	+0.328	.005	.005	3	3
BREAST	PINK1 →	+1.492	+0.394	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006848 vs HOOK3 — CNS

Explore this scatter interactively →