Mitochondrial transport

Across TCGA patient cohorts, RNA activity of the Mitochondrial transport pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are EEF2, MAP1A, and RPL11, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitochondrial transport activity versus EEF2 in GBM (Pearson r = -0.12).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	EEF2 →	-0.144	-0.020	.004	.001	3	5
BRCA	MAP1A →	+0.269	+0.012	.001	.002	3	5
HNSC	RPL11 →	-0.139	-0.049	.008	.006	3	4
LSCC	ATL1_S10 →	+0.650	+0.022	.002	.005	3	4
LSCC	TM6SF1 →	+0.337	+0.024	.007	.007	3	4
CCRCC	MAP9 →	+0.446	+0.026	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006839 vs EEF2 — GBM

Explore this scatter interactively →