Mitochondrial transport

Across TCGA cell cohorts, RNA activity of the Mitochondrial transport pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FAM72A, MED13, and POLR1A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FAM72A grouped by Mitochondrial transport-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	FAM72A →	+0.453	+0.884	.001	<.001	3	5
CNS	MED13 →	+0.567	+1.084	<.001	<.001	3	4
BLOOD_Leukemia	POLR1A →	+0.972	+1.157	<.001	.003	3	4
KIDNEY	ZNF236 →	+0.693	+1.175	.001	.001	3	3
KIDNEY	PTPN11 →	+0.558	+0.867	.007	.008	3	3
KIDNEY	MBD5 →	+0.837	+1.190	.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FAM72A by Mitochondrial transport activity — CNS

Explore this box plot interactively →