Mitochondrial transport

Across TCGA cell cohorts, RNA activity of the Mitochondrial transport pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are APOL3, SP140L, and SP100, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitochondrial transport activity versus APOL3 in LUNG_NSCLC_LUAD (Pearson r = 0.37).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	APOL3 →	+1.119	+0.148	.009	.002	3	6
BONE	SP140L →	+3.738	+0.377	<.001	.001	3	6
BONE	SP100 →	+4.800	+0.389	<.001	<.001	3	6
CNS	LCTL →	+1.446	+0.165	.001	<.001	3	5
BONE	SAMD9 →	+2.130	+0.412	.002	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	NCKAP5L →	+0.755	+0.264	.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006839 vs APOL3 — LUNG_NSCLC_LUAD

Explore this scatter interactively →