Serotonin transport

Across TCGA cell cohorts, RNA activity of the Serotonin transport pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EEF1A1, REEP5, and TSPAN10, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, EEF1A1 grouped by Serotonin transport-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	EEF1A1 →	-0.384	-1.065	.008	<.001	3	4
BLOOD_Leukemia	REEP5 →	+0.812	+1.284	.001	.005	3	4
LUNG_SCLC	TSPAN10 →	+0.636	+1.225	.008	<.001	3	4
SKIN	RPS11 →	-0.358	-0.728	.008	.005	3	4
CNS	RADIL →	+0.542	+0.817	.003	<.001	3	4
CNS	SMIM1 →	+0.397	+0.890	.009	<.001	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

EEF1A1 by Serotonin transport activity — LARGE_INTESTINE

Explore this box plot interactively →