Dicarboxylic acid transport

Across TCGA patient cohorts, RNA activity of the Dicarboxylic acid transport pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RNF2, ATP6V1C1, and ATP6V1F, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Dicarboxylic acid transport activity versus RNF2 in GBM (Pearson r = -0.50).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RNF2 →	-0.309	-0.033	<.001	<.001	3	6
LUAD	ATP6V1C1 →	+0.232	+0.031	<.001	.001	3	5
LUAD	ATP6V1F →	+0.155	+0.025	.005	.002	3	5
GBM	RENBP →	+0.522	+0.027	<.001	.003	3	5
GBM	CTSZ →	+0.440	+0.039	.002	<.001	3	5
UCEC	MSH6_S256 →	-0.773	-0.036	.004	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006835 vs RNF2 — GBM

Explore this scatter interactively →