Dicarboxylic acid transport

Across TCGA patient cohorts, RNA activity of the Dicarboxylic acid transport pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRBV5-4, SERPINA10, and SLFN11, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Dicarboxylic acid transport activity versus TRBV5-4 in UCEC (Pearson r = -0.11).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TRBV5-4 →	-0.719	-0.414	.008	.002	3	4
COAD	SERPINA10 →	+0.507	+0.322	<.001	.001	3	4
HNSC	SLFN11 →	-0.609	-0.317	.003	.005	3	4
COAD	PRF1 →	-0.896	-0.330	<.001	.005	3	4
HNSC	ARHGAP22 →	-0.523	-0.578	<.001	<.001	3	4
BRCA	CYRIA →	-0.656	-0.822	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006835 vs TRBV5-4 — UCEC

Explore this scatter interactively →