Dicarboxylic acid transport

Across TCGA cell cohorts, RNA activity of the Dicarboxylic acid transport pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SMIM12, DIS3L, and SYTL4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SMIM12 grouped by Dicarboxylic acid transport-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	SMIM12 →	-0.629	-1.074	.006	.003	3	4
STOMACH	DIS3L →	+0.700	+1.137	.001	<.001	3	4
LARGE_INTESTINE	SYTL4 →	+1.000	+0.721	.002	.006	3	3
LARGE_INTESTINE	NAA38 →	+0.960	+0.896	<.001	<.001	3	3
UPPER_AERODIGESTIVE_TRACT	DEDD2 →	-0.628	-1.287	.008	<.001	3	3
BLOOD_Lymphoma	ICMT →	+1.260	+1.657	.009	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SMIM12 by Dicarboxylic acid transport activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →