Water transport

Across TCGA patient cohorts, RNA activity of the Water transport pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NCL, NELFCD, and NELFB, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Water transport activity versus NCL in GBM (Pearson r = -0.33).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	NCL →	-0.408	-0.082	<.001	<.001	3	7
OV	NELFCD →	-0.253	-0.044	.001	<.001	3	7
LSCC	NELFB →	-0.279	-0.084	<.001	<.001	3	7
LSCC	FUS →	-0.328	-0.065	.004	.005	3	6
PDAC	PCF11_S489 →	-0.554	-0.060	<.001	.001	3	6
GBM	ELANE →	+1.164	+0.073	<.001	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006833 vs NCL — GBM

Explore this scatter interactively →