Water transport

Across TCGA cell cohorts, RNA activity of the Water transport pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARHGEF12, DONSON, and FAM126B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ARHGEF12 grouped by Water transport-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ARHGEF12 →	-1.699	-0.885	.007	<.001	3	5
LARGE_INTESTINE	DONSON →	+0.576	+0.758	.001	.001	3	5
LUNG_NSCLC_LUSC	FAM126B →	+0.720	+1.388	.006	.004	3	4
LUNG_NSCLC_LUSC	ZNF669 →	+0.791	+1.510	.002	.001	3	4
LARGE_INTESTINE	AFF4 →	+0.910	+1.053	.001	.002	3	4
LUNG_SCLC	ZGRF1 →	+1.042	+1.125	<.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ARHGEF12 by Water transport activity — BLOOD_Leukemia

Explore this box plot interactively →