Zinc ion transport

Across TCGA patient cohorts, RNA activity of the Zinc ion transport pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MSH2, NUP85, and SMARCD1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Zinc ion transport activity versus MSH2 in GBM (Pearson r = -0.36).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	MSH2 →	-0.539	-0.064	<.001	<.001	3	6
GBM	NUP85 →	-0.224	-0.083	<.001	<.001	3	6
GBM	SMARCD1 →	-0.344	-0.062	<.001	<.001	3	5
GBM	SMU1 →	-0.244	-0.055	<.001	.002	3	5
PDAC	SRSF2_T25 →	-0.604	-0.039	<.001	.001	3	5
LSCC	SSRP1 →	-0.442	-0.053	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006829 vs MSH2 — GBM

Explore this scatter interactively →