Manganese ion transport

Across TCGA patient cohorts, RNA activity of the Manganese ion transport pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SERPINB10, HK3, and ITGAM, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Manganese ion transport activity versus SERPINB10 in GBM (Pearson r = 0.54).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SERPINB10 →	+0.955	+0.112	<.001	<.001	3	9
GBM	HK3 →	+1.163	+0.149	<.001	<.001	3	9
GBM	ITGAM →	+0.869	+0.150	<.001	<.001	3	9
GBM	MNDA →	+1.077	+0.138	<.001	<.001	3	9
GBM	NCF1 →	+0.802	+0.133	<.001	<.001	3	9
GBM	NCF2 →	+0.855	+0.145	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006828 vs SERPINB10 — GBM

Explore this scatter interactively →