Manganese ion transport

Across TCGA patient cohorts, RNA activity of the Manganese ion transport pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GLIPR1, PTGES3_S44, and TCF20_S559, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Manganese ion transport activity versus GLIPR1 in COAD (Pearson r = 0.68).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	GLIPR1 →	+1.548	+2.072	.001	<.001	3	3
COAD	PTGES3_S44 →	-0.679	-1.002	<.001	<.001	3	3
OV	TCF20_S559 →	+1.218	+0.785	<.001	<.001	3	3
UCEC	PLP2 →	+0.594	+0.612	<.001	<.001	3	3
GBM	RIN2_S366 →	+0.505	+0.877	<.001	<.001	3	3
OV	SEC61B_S13 →	+0.920	+0.782	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006828 vs GLIPR1 — COAD

Explore this scatter interactively →