Iron ion transport

Across TCGA patient cohorts, RNA activity of the Iron ion transport pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are BUB3, CHERP, and TRIM33_S862, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Iron ion transport activity versus BUB3 in GBM (Pearson r = -0.56).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	BUB3 →	-0.276	-0.052	<.001	<.001	3	8
LSCC	CHERP →	-0.281	-0.051	<.001	<.001	3	8
LUAD	TRIM33_S862 →	-0.607	-0.042	<.001	<.001	3	7
GBM	PUF60 →	-0.338	-0.100	<.001	<.001	3	7
GBM	EFTUD2 →	-0.335	-0.114	<.001	<.001	3	7
GBM	RBM14_S582 →	-0.483	-0.081	.002	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006826 vs BUB3 — GBM

Explore this scatter interactively →