Iron ion transport

Across TCGA patient cohorts, RNA activity of the Iron ion transport pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VTN, NPR3, and CUL9, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Iron ion transport activity versus VTN in CCRCC (Pearson r = -0.14).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	VTN →	-0.494	-0.141	.004	.003	3	4
LSCC	NPR3 →	+1.423	+0.212	<.001	<.001	3	4
BRCA	CUL9 →	-0.274	-0.128	.004	.001	3	4
LSCC	EIF4EBP1P1 →	-0.447	-0.191	.002	.001	3	4
LSCC	CYFIP2 →	-0.849	-0.216	<.001	<.001	3	4
UCEC	MIRLET7G →	-1.277	-0.134	.003	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006826 vs VTN — CCRCC

Explore this scatter interactively →