Iron ion transport

Across TCGA cell cohorts, RNA activity of the Iron ion transport pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C1QBP, NOP2, and AHCY, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Iron ion transport activity versus C1QBP in LARGE_INTESTINE (Pearson r = -0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	C1QBP →	-0.910	-0.231	<.001	<.001	3	7
OESOPHAGUS	NOP2 →	-0.830	-0.186	.005	.002	3	6
BONE	AHCY →	-1.122	-0.229	<.001	.001	3	6
LUNG_SCLC	PAM16 →	-0.781	-0.195	.001	.001	3	6
BREAST	TRIM34 →	+1.174	+0.154	.003	<.001	3	5
OESOPHAGUS	MRPS25 →	-1.145	-0.168	<.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006826 vs C1QBP — LARGE_INTESTINE

Explore this scatter interactively →