Copper ion transport

Across TCGA patient cohorts, RNA activity of the Copper ion transport pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GTF3C4, SRRM2_S1424, and ACTN1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Copper ion transport activity versus GTF3C4 in LSCC (Pearson r = -0.44).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	GTF3C4 →	-0.326	-0.082	<.001	<.001	3	7
GBM	SRRM2_S1424 →	-0.517	-0.088	<.001	<.001	3	7
LSCC	ACTN1 →	+0.381	+0.087	<.001	<.001	3	7
GBM	VCL →	+0.429	+0.104	<.001	<.001	3	7
LUAD	FILIP1L_S1041 →	+0.746	+0.051	<.001	.003	3	7
LSCC	CALD1_S759 →	+0.867	+0.067	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006825 vs GTF3C4 — LSCC

Explore this scatter interactively →