Copper ion transport

Across TCGA cell cohorts, RNA activity of the Copper ion transport pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MYLK3, SDC2, and RNPEP, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MYLK3 grouped by Copper ion transport-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	MYLK3 →	+0.273	+0.821	.004	<.001	3	4
LUNG_NSCLC_LUAD	SDC2 →	+2.128	+0.951	.005	.001	3	4
SKIN	RNPEP →	+0.707	+1.270	.009	.002	3	4
CNS	PHC2 →	-0.629	-0.964	.003	.001	3	3
OVARY	AIF1L →	+1.855	+1.103	.008	.001	2	4
OVARY	TAX1BP3 →	-0.665	-1.263	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MYLK3 by Copper ion transport activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →