Cobalt ion transport

Across TCGA patient cohorts, RNA activity of the Cobalt ion transport pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TIMM44, U2AF2, and CCDC58, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cobalt ion transport activity versus TIMM44 in OV (Pearson r = -0.28).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	TIMM44 →	-0.522	-0.061	.002	.007	2	8
GBM	U2AF2 →	-0.292	-0.098	<.001	<.001	3	7
OV	CCDC58 →	-0.506	-0.076	<.001	<.001	3	7
OV	DDX51_S83 →	-0.641	-0.076	<.001	<.001	3	7
GBM	LCP2 →	+0.528	+0.087	<.001	<.001	3	7
OV	NCL_S563 →	-0.952	-0.061	.007	.003	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006824 vs TIMM44 — OV

Explore this scatter interactively →