Chloride transport

Across TCGA cell cohorts, RNA activity of the Chloride transport pathway is significantly associated with the shRNA dependency of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC30A5, INPPL1, and DACH2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SLC30A5 grouped by Chloride transport-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	SLC30A5 →	+0.203	+1.329	.001	<.001	3	4
CNS	INPPL1 →	-0.242	-0.724	.004	.008	3	4
SOFT_TISSUE	DACH2 →	-0.283	-1.678	.001	<.001	3	4
SOFT_TISSUE	EPRS1 →	-0.339	-1.523	.003	<.001	3	4
KIDNEY	CPXM1 →	-0.428	-1.412	.002	<.001	3	4
BONE	NLRP12 →	-0.308	-1.332	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SLC30A5 by Chloride transport activity — KIDNEY

Explore this box plot interactively →