Chloride transport

Across TCGA cell cohorts, RNA activity of the Chloride transport pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BMF, ZNF491, and CPQ, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, BMF grouped by Chloride transport-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	BMF →	-1.060	-0.774	.001	<.001	3	4
CNS	ZNF491 →	-0.616	-0.841	.007	.003	3	4
LUNG_NSCLC_LUSC	CPQ →	-2.730	-1.411	.003	.002	3	3
CNS	SLC2A11 →	-1.002	-1.092	.008	<.001	3	3
OESOPHAGUS	BTBD11 →	-1.237	-0.245	<.001	<.001	3	3
SOFT_TISSUE	SLC66A2 →	-1.238	-1.583	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

BMF by Chloride transport activity — CNS

Explore this box plot interactively →