Monoatomic anion transport

Across TCGA cell cohorts, RNA activity of the Monoatomic anion transport pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LRRC34, BMF, and SLC7A1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, LRRC34 grouped by Monoatomic anion transport-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	LRRC34 →	-1.579	-0.217	.009	.003	2	5
CNS	BMF →	-1.473	-0.825	<.001	.001	3	4
LUNG_NSCLC_LUSC	SLC7A1 →	+1.167	+1.398	.003	.004	3	4
LUNG_NSCLC_LUSC	CCDC159 →	-1.287	-1.008	.002	.001	3	4
PANCREAS	GSTZ1 →	-0.755	-0.169	.004	.002	3	3
LUNG_NSCLC_LUSC	TMEM232 →	-1.012	-1.757	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LRRC34 by Monoatomic anion transport activity — URINARY_TRACT

Explore this box plot interactively →