Monoatomic anion transport

Across TCGA cell cohorts, RNA activity of the Monoatomic anion transport pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GLIS2, KDM3A, and PDK1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Monoatomic anion transport activity versus GLIS2 in LARGE_INTESTINE (Pearson r = -0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GLIS2 →	-1.654	-0.173	<.001	<.001	3	5
PANCREAS	KDM3A →	+0.716	+0.252	<.001	<.001	3	5
SOFT_TISSUE	PDK1 →	+0.960	+0.285	.004	<.001	3	5
CNS	EIF3H →	+0.692	+0.193	.007	.002	3	4
UPPER_AERODIGESTIVE_TRACT	CCDC12 →	+0.937	+0.222	.004	.003	3	4
LARGE_INTESTINE	ABHD14B →	+0.826	+0.128	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006820 vs GLIS2 — LARGE_INTESTINE

Explore this scatter interactively →