Phosphate ion transport

Across TCGA patient cohorts, RNA activity of the Phosphate ion transport pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ZYX, CNN2, and CNN3, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Phosphate ion transport activity versus ZYX in UCEC (Pearson r = -0.01).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ZYX →	+0.388	+0.051	.005	.007	3	8
OV	CNN2 →	+0.685	+0.047	<.001	<.001	3	8
OV	CNN3 →	+0.617	+0.049	.001	<.001	3	8
OV	DOCK10 →	+0.460	+0.063	<.001	<.001	3	8
OV	DPYD →	+0.564	+0.052	<.001	<.001	3	8
GBM	LGALS9 →	+0.540	+0.070	.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006817 vs ZYX — UCEC

Explore this scatter interactively →