Phosphate ion transport

Across TCGA patient cohorts, RNA activity of the Phosphate ion transport pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDON, XPR1, and CCDC7, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Phosphate ion transport activity versus CDON in LSCC (Pearson r = -0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CDON →	-0.801	-0.258	.004	.005	3	4
LSCC	XPR1 →	+0.431	+0.199	<.001	.001	3	4
LSCC	CCDC7 →	-0.596	-0.270	<.001	.003	3	4
CCRCC	CTSZ →	+0.430	+0.397	.002	.006	3	3
LSCC	GSDMC →	+1.580	+0.366	<.001	<.001	3	3
CCRCC	GKAP1 →	-0.260	-0.414	.009	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006817 vs CDON — LSCC

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