Sodium ion transport

Across TCGA patient cohorts, RNA activity of the Sodium ion transport pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MCF2L, ATP1A1_S16, and DEK, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sodium ion transport activity versus MCF2L in GBM (Pearson r = 0.45).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	MCF2L →	+0.333	+0.031	<.001	<.001	3	7
OV	ATP1A1_S16 →	+1.037	+0.022	<.001	.003	3	6
OV	DEK →	-0.356	-0.017	.005	.005	3	6
GBM	DDX41 →	-0.289	-0.031	<.001	<.001	3	6
LSCC	NUP153 →	-0.220	-0.024	.004	<.001	3	6
BRCA	PPFIBP2_S414 →	+0.952	+0.015	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006814 vs MCF2L — GBM

Explore this scatter interactively →