Sodium ion transport

Across TCGA cell cohorts, RNA activity of the Sodium ion transport pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GORASP2, DCAF6, and ATP1A1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sodium ion transport activity versus GORASP2 in UPPER_AERODIGESTIVE_TRACT (Pearson r = -0.72).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	GORASP2 →	-0.931	-0.570	.002	.001	3	6
UPPER_AERODIGESTIVE_TRACT	DCAF6 →	-1.095	-0.543	.005	.001	3	5
BLOOD_Myeloma	ATP1A1 →	+2.101	+1.283	.006	.001	3	5
UPPER_AERODIGESTIVE_TRACT	NDUFS2 →	-0.884	-0.287	<.001	.002	3	5
LARGE_INTESTINE	ATP1B1 →	+2.034	+0.212	<.001	.006	3	4
SOFT_TISSUE	SOX13 →	+2.017	+0.228	<.001	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006814 vs GORASP2 — UPPER_AERODIGESTIVE_TRACT

Explore this scatter interactively →