Potassium ion transport

Across TCGA patient cohorts, RNA activity of the Potassium ion transport pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are AKR7A3, GOT1, and ECHS1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Potassium ion transport activity versus AKR7A3 in BRCA (Pearson r = 0.35).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	AKR7A3 →	+0.925	+0.018	<.001	<.001	3	6
GBM	GOT1 →	+0.540	+0.035	<.001	<.001	3	6
CCRCC	ECHS1 →	+0.335	+0.020	.006	.006	3	6
GBM	P4HA2 →	-0.748	-0.033	<.001	.005	3	5
LUAD	LDHD →	+0.425	+0.017	<.001	.002	3	5
BRCA	UTP6 →	-0.405	-0.016	<.001	.007	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006813 vs AKR7A3 — BRCA

Explore this scatter interactively →