Potassium ion transport

Across TCGA patient cohorts, RNA activity of the Potassium ion transport pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRKG1, ACTA2, and PDLIM3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Potassium ion transport activity versus PRKG1 in UCEC (Pearson r = 0.11).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PRKG1 →	+1.056	+0.663	.004	.008	3	6
OV	ACTA2 →	+1.395	+0.268	.001	.009	3	5
OV	PDLIM3 →	+1.176	+0.265	.001	.008	3	5
BRCA	COL3A1 →	+1.696	+0.690	<.001	<.001	3	5
OV	HSPB7 →	+0.671	+0.212	.001	.003	3	5
OV	PLN →	+1.337	+0.215	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006813 vs PRKG1 — UCEC

Explore this scatter interactively →