Potassium ion transport

Across TCGA cell cohorts, RNA activity of the Potassium ion transport pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NLRP12, DHX57, and CTLA4, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NLRP12 grouped by Potassium ion transport-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	NLRP12 →	-0.288	-1.581	.003	.003	3	8
OVARY	DHX57 →	-0.310	-0.885	<.001	.004	3	7
BONE	CTLA4 →	-0.289	-1.502	.009	.003	3	6
CNS	VSX2 →	-0.220	-1.103	.001	<.001	3	5
BLOOD_Myeloma	KCNA5 →	-0.486	-1.970	.002	<.001	3	5
LUNG_NSCLC_LUAD	KCNK3 →	-0.133	-0.670	.004	.004	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NLRP12 by Potassium ion transport activity — BLOOD_Myeloma

Explore this box plot interactively →