Xenobiotic metabolic process

Across TCGA patient cohorts, RNA activity of the Xenobiotic metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are AKR1C3, RFC2, and AKR1B10, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Xenobiotic metabolic process activity versus AKR1C3 in LSCC (Pearson r = 0.58).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	AKR1C3 →	+1.511	+0.058	<.001	<.001	3	8
BRCA	RFC2 →	-0.371	-0.029	<.001	<.001	3	7
LSCC	AKR1B10 →	+2.205	+0.056	<.001	<.001	3	7
BRCA	HNMT →	+0.596	+0.032	<.001	<.001	3	7
LUAD	RFC1_T506 →	-0.781	-0.035	.001	<.001	3	6
BRCA	RPL12_S38 →	-0.981	-0.026	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006805 vs AKR1C3 — LSCC

Explore this scatter interactively →