Xenobiotic metabolic process

Across TCGA patient cohorts, RNA activity of the Xenobiotic metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HROB, KIF18B, and DDX12P, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Xenobiotic metabolic process activity versus HROB in UCEC (Pearson r = -0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HROB →	-0.621	-0.190	.005	.002	3	6
BRCA	KIF18B →	-1.258	-0.236	<.001	<.001	3	6
BRCA	DDX12P →	-0.894	-0.186	<.001	.001	3	6
BRCA	FANCG →	-0.459	-0.179	<.001	<.001	3	6
GBM	DBF4 →	-0.665	-0.228	<.001	<.001	3	6
GBM	DPH7 →	-0.333	-0.151	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006805 vs HROB — UCEC

Explore this scatter interactively →