Xenobiotic metabolic process

Across TCGA cell cohorts, RNA activity of the Xenobiotic metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PNN, MROH8, and TBC1D3L, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PNN grouped by Xenobiotic metabolic process-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	PNN →	-1.041	-0.947	.001	.008	3	4
LUNG_SCLC	MROH8 →	-1.134	-1.131	.008	.006	3	4
LUNG_SCLC	TBC1D3L →	-1.913	-1.088	.002	.003	3	4
BLOOD_Leukemia	NHSL1 →	-1.538	-1.193	<.001	<.001	3	4
LARGE_INTESTINE	TRAPPC6B →	-0.712	-0.804	<.001	.009	3	4
LIVER	CD70 →	+4.153	+1.171	.001	.006	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PNN by Xenobiotic metabolic process activity — LUNG_SCLC

Explore this box plot interactively →