Superoxide metabolic process

Across TCGA patient cohorts, RNA activity of the Superoxide metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MYBBP1A, WIPF1, and ADA2, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Superoxide metabolic process activity versus MYBBP1A in LSCC (Pearson r = -0.49).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MYBBP1A →	-0.468	-0.074	<.001	<.001	3	10
UCEC	WIPF1 →	+0.439	+0.064	<.001	<.001	3	9
BRCA	ADA2 →	+0.470	+0.029	<.001	<.001	3	9
UCEC	IL16 →	+0.613	+0.061	<.001	<.001	3	9
GBM	DCN →	+0.922	+0.054	<.001	<.001	3	8
COAD	FTL →	+0.676	+0.023	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006801 vs MYBBP1A — LSCC

Explore this scatter interactively →