Superoxide metabolic process

Across TCGA patient cohorts, RNA activity of the Superoxide metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NCF2, ITGAX, and FCAR, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Superoxide metabolic process activity versus NCF2 in UCEC (Pearson r = 0.35).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NCF2 →	+0.832	+0.157	.002	.008	3	8
GBM	ITGAX →	+1.033	+0.207	<.001	.001	3	8
GBM	FCAR →	+0.808	+0.270	<.001	<.001	3	8
GBM	C1orf162 →	+0.737	+0.190	<.001	.007	3	8
GBM	TLR8 →	+0.746	+0.176	<.001	.004	3	7
GBM	SAT1 →	+0.900	+0.266	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006801 vs NCF2 — UCEC

Explore this scatter interactively →