Superoxide metabolic process

Across TCGA cell cohorts, RNA activity of the Superoxide metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AKNAD1, PSMB10, and CLUH, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, AKNAD1 grouped by Superoxide metabolic process-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	AKNAD1 →	+1.763	+0.998	.005	.001	3	5
OESOPHAGUS	PSMB10 →	+0.817	+1.075	.002	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	CLUH →	-1.064	-0.957	<.001	.005	3	4
LARGE_INTESTINE	P2RY1 →	-1.776	-0.894	<.001	<.001	3	4
LARGE_INTESTINE	WDR18 →	-0.707	-1.040	.002	.003	3	4
UPPER_AERODIGESTIVE_TRACT	EIF3B →	-1.009	-1.075	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AKNAD1 by Superoxide metabolic process activity — LUNG_SCLC

Explore this box plot interactively →