Superoxide metabolic process

Across TCGA cell cohorts, RNA activity of the Superoxide metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NQO1, TMEM265, and TUBB2A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Superoxide metabolic process activity versus NQO1 in LUNG_SCLC (Pearson r = 0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	NQO1 →	+2.529	+0.185	.006	.002	3	5
BLOOD_Lymphoma	TMEM265 →	-0.862	-0.122	.008	.008	3	4
BLOOD_Myeloma	TUBB2A →	+1.677	+0.202	.003	.001	3	4
BLOOD_Leukemia	MPPE1 →	-0.593	-0.179	.003	.001	3	4
SOFT_TISSUE	CAMK1 →	+3.660	+0.363	.004	.005	3	4
CNS	PRDX2 →	+2.291	+0.226	.002	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006801 vs NQO1 — LUNG_SCLC

Explore this scatter interactively →