Protoporphyrinogen IX biosynthetic process

Across TCGA patient cohorts, RNA activity of the Protoporphyrinogen IX biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DPF1, GABPB1-AS1, and CPEB3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protoporphyrinogen IX biosynthetic process activity versus DPF1 in LSCC (Pearson r = -0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	DPF1 →	-0.518	-0.096	<.001	<.001	3	5
PDAC	GABPB1-AS1 →	+0.515	+0.119	.001	<.001	3	4
BRCA	CPEB3 →	+0.533	+0.143	<.001	.001	3	4
GBM	LMO2 →	+0.694	+0.095	.001	.001	3	4
LUAD	PGM5 →	+0.735	+0.114	.002	.001	2	5
CCRCC	CLEC3B →	+1.029	+0.111	.003	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006782 vs DPF1 — LSCC

Explore this scatter interactively →