Protoporphyrinogen IX biosynthetic process

Across TCGA cell cohorts, RNA activity of the Protoporphyrinogen IX biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MXRA7, MAP3K3, and SDC3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MXRA7 grouped by Protoporphyrinogen IX biosynthetic process-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	MXRA7 →	-1.546	-1.323	.005	<.001	3	4
LUNG_NSCLC_LUSC	MAP3K3 →	-1.112	-1.847	.001	<.001	3	4
LUNG_NSCLC_LUSC	SDC3 →	-3.277	-1.910	<.001	<.001	3	4
LUNG_NSCLC_LUSC	DDX60L →	-1.906	-1.948	.008	<.001	3	4
LUNG_SCLC	DAPK3 →	-0.888	-1.511	.002	.003	3	4
LARGE_INTESTINE	HYI →	-0.837	-0.809	.001	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MXRA7 by Protoporphyrinogen IX biosynthetic process activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →